Friday, December 31, 2010

Poetry to Improve the World

One of the several possible Poetry Bus challenges for Monday is to write about what we would do to improve the world. Jeanne Iris says so, right here.
Here's a first go. Perhaps a proper pome will come to me over the weekend; if that happens I'll post again!
stop bitching
distribute chocolates
more cats
don't be infected by the bitchiness of other people's bitching, just fix the problem
pet the cats
no allergies
play with your toys
make sure everybody has toys
say "yes"
have another chocolate
take time
to the cats purring

Thursday, December 30, 2010


Last workday of the year and we’re down to four people. After noon, maybe three, maybe two. Perhaps I won’t be there to count.
It’s been a calm week at the lab. I like this time of year, when the year-end rush is over (or given up on!), everyone’s on vacation, finally a bit of peace between the two party weekends. It might be nice to travel and see my family for the holidays, but that always turns out to be so hectic and bothersome. Stations and airports are crammed, and may close for bad weather for any length of time, plus since so many people are traveling it’s more expensive, more hassle, and there’s never anyplace to sit down. Forget it! Travel in the off-season.
So what sort of year has it been?
Every year, it always seems to have the busiest year ever. Which in a way is true, since the annual activity report shows that, yes, we did churn out more reports than ever before. (This doesn’t have to mean we did more work, just that we were more successful at it. No matter how many times you repeat an assay, only the one that worked becomes a result.)
By a lot of measures, I was busier, but not by one of the measures that my boss has really been leaning on me about: publishing. The lab has three new permanent employees, which makes the lab as a whole busier, which makes me busier because I’m the one to manage all those people. The lab must attain accreditation in the near-ish future, which may seem far away, but we are so far away from being accreditable that it’s urgent to act now. I can’t delegate much of that work until I come up with the framework for how to do it.
Translation: It was the year I reached my managerial capacity.
That’s why it feels like the heaviest year ever.
There have been worse years. The one I spent as a post-doc at Yale was pretty awful. The second year of grad school was horrid.
But this year I feel I’ve really done all I could to make things run, and it’s just quantitatively too much. I’m tired. Thank goodness this week is just coasting, or I would collapse.
On the other hand, this was also the year I got off my duff and joined some new social circles. Italian on Thursdays, which I fully intend to go test in Italy. Bridge on Wednesdays and assorted Saturdays, where I’ve become an appreciated partner. I’m learning people’s names, becoming comfortable playing a session without too many mistakes. Last night I acquired a regular partner, even, so I won’t always be arriving to play and have to wait to see who else might show up on their own. It’s neat to become part of the group, not just a visitor.
Travel happened. Of course!
There was San Sebastian, on the spur of the moment. Wonderful place. Must eat my way across Spain some day. Poitiers for one of those long weekend explorations I really must do more often. Strasbourg for a conference, in the January snow.
And a magnificent road trip to see my family and some friends in the States. We had everyone together for once, as only happens every few years. I even picked up my last Southern state: Alabama. Just three to go!
And New Year’s Eve? well, I think I’ll just relax at home. If the weather’s good, a day hike or an overnight train somewhere might be in order. I’ll work on Monday’s Poetry Bus ticket, finish up the Best of 2010 photo album, and take plenty of naps in preparation for the full-speed-ahead first Monday of the year.

Wednesday, December 29, 2010

Oh, a talk, erm...

So I’m writing this paper on a project that my boss imposed on the laboratory. As you might know, because I’m a complaining sort of blogger at times, and I’ve wailed about this thing before. The idea was to go fishing for mutations with our fancy new sequencer in a kind of tumor whose origins remain mysterious. We couldn’t cover the whole ocean of possibilities, so we stocked the pond with a reasonable list of candidates, and indeed hauled out a bunch of mutations. Six genes times five tumor characteristics isn’t that much analysis to do.
Over the summer, I sent around a draft of the paper, and it came back that it might be very useful to complement the mutation information with info on the expression of some pretty common markers that interact with the genes we found mutated. That would tell a more complete story, and the work wouldn’t take long. Just five protein markers.
Five isn’t too many.
But every time you add a marker, you need to compare it to the results of each one of the others. The amount of number crunching to do goes up exponentially, and the different possible combinations of results far exceeds the number of tumors we had to look at.
Fine. I did all that analyzing and hoped to find the new data neatly confirming what we were learning from the mutations and consolidating the tumors into a small number of groups with similar biology. Getting a handle on the biology might give us new therapeutic options.
Only, no, that didn’t happen. For every two the same, one was different, any way you looked at it.
It was like thinking that (kilt + bagpipe) might = Scots, and then assessing haggis just to be sure.
Well: kilt could be Scot or Halloween, bagpipe could be Scot or Breton, and haggis could be Scot or just weird. And none of the bona fide Scots are required to have kilt or bagpipe or haggis at all!
Things just fall into chaos when you don’t have enough samples for the p values to get really small.
So the new paper has been written and sent around with a plea for advice (and not just my awful English, please!), and after a month only one of my faithful coauthors has responded. She, alas, seems to have dug up the old version to advise me on.
Meanwhile, the guy whose idea this all was in the first place remains silent. Oh, except to schedule me for a public talk on this very project a mere three weeks from now.
Thanks. I’m honored.

Tuesday, December 28, 2010

weekend walk

I had a cold over Christmas, and on the 25th didn't budge from the house. Never quit my bathrobe - just went from nap to book to dvd. With a few trips to the kitchen.
Sunday was better. We had half an inch of snow in the yard on Saturday, and I hoped there was rather more up on the nearby hills. It was a bright day and very cold, but I bundled up with extra socks, and tights under my jeans, and many layers under my parka. Hat, mittens, extra handkerchiefs, the whole nine yards. Last year I picked up some of those glove-mitten things, where the mitten over the fingertips is a big flap you can pin back, revealing gloves that don't cover the last finger joint. Perfect for maneuvering a camera without taking off the handwarmers. They made a new trailhead that leads up the Gergovia plateau, and it passes through this huge yard full of odd metal sculpture.

Plenty of mistletoe overhead.

Icicles on the windmill.

Critters had been all over this road. Half a mile down, I discovered why none of the many human traces went that way - it was a dead end at one of the groundwater monitoring sites.

Not much snow on the surrounding hills at all.

Cows have been moved into their barns.

Have a good week!

Monday, December 27, 2010

Rule: do not regift to the original owner.

This week’s poetry bus is being driven by Muse Swings, who set us the task of writing about our worst/most useless/most disturbing/most painful/stupidest/ugliest/least appreciated/most disastrous Christmas present. A nice antidote to all this good cheer going on.
I’m not sure a poem is forthcoming, but I will tell you about my most disappointing gift.
I was 8 or 10, and the apple of my grandfather’s eye. When he came to the house and deposited the presents for my brothers and me under the tree, he held mine out with a mischievous smile and said he just knew I was really going to love it.
Oh my, I thought, I’m going to love it! What could it possibly be? The package was long and thin, with something lumpy inside that rattled when you turned it upside-down. I spent a whole week wondering what could it be, with such an odd shape, going back again and again to shake, squeeze and fondle.
Finally, Christmas came.
Usually, we’d go straight for the gifts from “Santa”, because they were always the most fun. Santa always gave toys, never a pullover. This time I went straight for my mysterious gift from Granddad, tore it open at last, and what dropped into my lap but an old string of beads of mine I’d forgotten at his house over the summer.
Oh, those.
Hey, that’s no present at all.
It was as if my grandfather had given me nothing. I hope I kept from crying, but I don’t think I did. I know he really did think I’d be thrilled.
So, belatedly, Thank you!

Friday, December 24, 2010

Slumdog Irony

On this eve of Christmas eve, I'm home with the cats, sick with a headcold and pampering myself such as I can,
...smoked salmon and toast, a nice Reisling, hundreds of white christmas lights strung around the room, chocolates...
and I'm about to watch Slumdog Millionaire.
For the first time.
Yes, yes, I've never seen it. I miss a lot of films because I don't want to see the dubbed version first, and the original only stays in the theater for a week (if at all). But there was this great sale on DVDs over the summer, and I've got several left to watch for the first time.
This particular movie, with all the noise about it afterwards - how the child actors in it were paid a pittance and went right back to the slums so poignantly portrayed - I just wonder how experiencing the bouhaha before the movie might change my viewing.
I must say, that is one great film.
The fairy tale ending, however, is a little too good to be true. It's as if the polemic around the moviemakers making a killing but the cast not rising out of their poverty is a continuation of the film, a next chapter in which you see, no, the fairy tale doesn't last. It's an epilogue that tones down the sticky sweetness of the end, coming back to reality.

Tuesday, December 21, 2010

Weaver's Star Poetry Bus

Wait for me! Wait for me!
Sorry I'm late this week for the bus. The Weaver of Grass suggested Star, take it as you will. So here we are:

It was shining in the north
didn't look so far away
looked as if you could touch it
if your finger were just a bit longer.
Let's go there, she said,
We'll see it up close
See what it really is.
So they went
across the fields and beyond the river, up the mountainside
They went through villages and cities and saw things they'd never seen before
They went through place where the language was strange
and the food indescribable
They saw new friends and old relatives,
were waylaid, made progress
they went on and on, as the seasons turned around them
forever on, crossing oceans, growing old.
They journeyed until they were as close as they could get
Leap high and catch it!
But it was just as far away
as always.
Catch the bus here!

Saturday, December 18, 2010

IPYPIASM in action

Yes, yes, I did go out this morning and slip some poems (alright. I admit it's just copies of one poem. But I figure that no particular person is going to find more than one of them, so it doesn't matter they're all the same.) Poem in a pocket.
Poem pretending to be shoes.

Poem among our Fabulous National Champion Rugby Team's books.

Poem in the chocolate Santas.

And finally one in the coffee maker aisle, a hurried shot as the salesperson came up, wanting to know why I was taking pictures of the merchandise. Thought I was a spy from a rival store!
Uh, no, just checking this is the right brand...
What it says is here.


Friday, December 17, 2010

Holiday cards

I love getting holiday cards. Finally some mail that’s cheerful and fun and personal!
I received a card yesterday from a close relative, one of those studio photo montages of the family in their finery. Flipped it over to read the message, and it was just blank.
I’ve been checked off a list.

I was really irritated. From cousins I’ve seen twice in my life one might expect a simple signature. But after having sent a package of cottony/wooly items of my own design and execution, plus some chocolates (they will like the chocolates, at least) off to them just last week, it’s kind of a splash of icewater to get this card. I was hoping for a letter, some news, something personal that confirms yes, we are family.
Then I remind myself that it’s not a race, no scorecard. So what if I sent them something? That’s up to me. There’s no quid pro quo going on.
What do holiday cards mean to me, anyway? That might have nothing to do with what they mean to my relatives.
In the chilly evenings of the end of the year, I like to take the time and catch up, or at least connect, with my friends and family, and writing holiday cards is a large part of that. I love to write, and all year long I tell myself I should find time to write to people (not just to the mostly invisible audience of the blog), and all year long I don’t get around to it. Card season is the warning light that I’ve really got to get down to it. Sitting in a corner of a busy pub, with a glass and a fountain pen and a stack of cards is a great way of passing an hour, repeat as necessary.
Some years I write reams. I include extra pages in with the card, which is crammed with writing top to bottom and maybe some on the back.
(yes, this really did happen)
(yes, I know it’s been a while)
(No, I won’t put it in the past tense and admit it will not happen again).
Then I got busier, or tired-er, and didn’t put anything more than would fit on the left side of the card. Now I’m down to writing some heartfelt but not terribly original greetings and wishes, in script that is a bit larger than necessary, and I’ll be happy to write to everyone if even just a little bit.
What I like about sending cards is taking the time and sending a personal message. If there’s a pre-printed message, I add one of my own, but usually the whole message is mine. This is me. I’m wishing you well.
What I like about sending cards is imagining my card being placed on a mantle among the others, so colorful and diverse, in a soul-warming bouquet of happiness and good thoughts.
There is, of course, a second motive to all this sending.
Send me cards! Fill my mantle (actually, I string a ribbon along the wall or across the room, and hang them on it). Say hello. Say you love me and hope I have a wonderful new year.

Friday Photo Shoot Out: Red

I'm not very well prepared for this week's shootout, but with red being my favorite color, I can hardly miss it when taking pictures in the house. These are all from the archives. Red rug in the bedroom.
Red cover on the armchair.

And a red throw on the couch.
More Shootouts here!

Thursday, December 16, 2010


That's International Put Your Poem In A Shop Month, for you reasonable people who do not concern themselves with leaving small pieces of paper in mercantile establishments. The rest of us, we know what it means.

Thing is, all the shops around here are full of french people. They’re expecting french poems. For a while I was thinking to write my missives in English, as I usually do, but it's possible that the surprise of coming upon a random poem like that is startling enough and if it were in English people would just crumple it up and toss it aside. So I've come up with this:
Le soleil
Il vient tard, il part tôt
Occupé avec ses soucis australs
Si nous, on fait un gros, gros fête
Plein de champagne, plein de cadeaux
Revient-il nous voir ?


and will be printing a bunch this evening for placement on Saturday.

Wish me luck!

Ah, yes, that's:

The sun

comes late, leaves early

occupied with his southern concerns.

If we have a great big party

with lots of champagne, lots of presents

Would he come back to see us?

Monday, December 13, 2010

this & that

The jam collection. It was a tough pick which one we can do without, but finally it was decided:
This one is off to South Carolina. The jam; not the wind-ups. They're off to Scotland.

And the cat tree, strategically placed in front of the radiator, is at last fully occupied. In about the right order!

Friday, December 10, 2010

The penultimate Cat of the Month: Sienne.

Sienne is small and skinny. Maybe it’s just the marks on her face, but she looks scowly all the time. And she’s got this whiny complaining meow. Just how some cats are.
The other cats are classic feline layabouts whenever they’re inside, but Sienne likes to play. And play, and play. There’s a whole collection of things under the kitchen cupboard/table that I’m not really looking forward to finding again when I move some day. Anything at all that ends up on the floor there is great fun at night, until it ends up out of reach.
Then there’s the Shoelace. Hours of fun can be had chasing the Shoelace as it is dragged along the floor and over the armchair (where Bandersnatch is trying to sit with some dignity).
Sienne is afraid of people, except for my brother. For four years now I’ve had the same guy come feed the beasts while I’m away, and he has never once even caught a glimpse of her.
Sienne does not go out. Well, she will go out if I’m out in the yard. But she doesn’t go out when I leave for work, or overnight, like the others do. She’s a homebody cat. She likes to be on things. On the towels, on the desk, on the tall armoire, on whatever there is to be on.

Thursday, December 9, 2010

The presents!!

Has it been a week already?
What? More than a week?
I'd better get on the ball, then, if I'm going to get (two of) these out in Saturday's mail. I have just printed out the list of our seven participants. Cut it up. Folded up the bits. Picked three.

The winners of the Fabulous Present Giveaway are.....
... and...
I was thinking of assigning the gifts randomly, but we all know how Titus feels about small windup toys. And then there's a warm scarf in dark green wool & alpaca that's shaping up very nicely, but Mark lives in the land of No Wooly Scarves Necessary, so that may be better with our friend steven of the Frozen North. Send me your snail mail addresses by email, and happiness is on it's way!

for T

well, yes, it's sideways (I can set the camera down on it's side, but not upright. Little design fault there. And Blogger won't let you turn a video sideways.) And the lighting is all red. But I know you want to see more, Titus!

Wednesday, December 8, 2010

ABC Wednesday: U

For this ABC Wednesday, I bring you this special documentary film featuring the prototype robot UB445.


Monday, December 6, 2010

get it while it's cold

Just a few shots in the back yard from last week's snow. We didn't get quite enough to shut the town down for a day off, or even properly cover the yard. I was lucky there was some left Saturday. It's gone now.
Where the melt drips off the eaves.
Queen Anne's lace nice & frosty.

And a very late apple.

Sunday, December 5, 2010


This week's Poetry Bus is driven here by Kat, and our task is to take the name of our favorite pub, turn that into characters, and write a fun poem with these characters. Well, my favored place for a beer and a big-screen rugby match happens to be called the Garden Ice. Who knows why. Neither "garden" nor "ice" is french, and when you put them together it still doesn't say anything.

I leapt up in the morning
happy for Saturday
bright sun through the window
cats fervently wanting out
Let's go out and pick fall leaves from the lawn
and taste the last apples from the trees.
I open the door
and the cats come barreling back in
It's cold out, Mom!
the garden is covered in ice!
December has come.

Wednesday, December 1, 2010


Today at Have Genes will Travel, we're getting into the end-of-year spirit. It's a spur-of-the-moment thing, and it may take me until the weekend to get pictures up, but here we are: NanU's Fabulous Present Giveaway. Just leave me a comment saying you're in, and I'll hold a drawing for the following gifts (worldwide postage included):

1. A jar of home-made jam. There's apricot-thyme, apricot-ginger, apricot-lavender, blueberry, cherry, and blackberry left in the cupboard, so specify a preferred flavor if you have one.

2. A scarf that is yet to be knitted (don't worry about that - scarves go quickly!). Cotton, wool, alpaca, and rayon available.

3. A pair of wind-up dinosaurs, about 2 inches tall.